The College of Pharmacy, University of Kufa discussed a master dissertation on the preparation and evaluation of ex vivo liposomes loaded with carvedilol to enhance solubility by the postgraduate student, Mr. Hussein Saeed Al-Sarraf.

The dissertation highlighted improving solubility and enhancing the release of carvedilol, a poorly soluble drug belonging to class II in the biopharmaceutical classification system, by encapsulating it within liposome nanocarriers and the drug formulation was optimized using the Design-Expert® 13 statistical design methodology.

The dissertation highlighted the successful preparation of 17 liposome formulations with homogeneous nanoparticle sizes and high encapsulation efficiency exceeding 80%, with a clear influence of lipid components on their physicochemical properties. 

The dissertation recommended the need for future in vivo pharmacokinetic and pharmacodynamic studies to verify improved bioavailability, as well as the development of an optimal oral pharmaceutical form using protective techniques such as polyethylene glycol (PEGylation) or polymer coating to enhance stability in the gastrointestinal tract.