College of Pharmacy, University of Al-Mustansiriyah discussed a Ph.D. thesis polymorphisms of the MTHFR Gene in patients with thromboembolic disorders and hyperhomocysteinemia. The thesis  aimed at investigating the association between MTHFR Gene polymorphisms with ischemic heart disease, stroke and venous thrombotic diseases. The thesis demonstrated that the true genetic effects of the MTHFR Gene polymorphism using haplotype-based methods to analyze all genetic polymorphisms were the potential risk of hypertension, cardiovascular disease and stroke with its complications. The thesis concluded that patients who carried the AC genotype of the A1298C variant had a 3.5 times greater risk of heart disease, stroke and venous thrombosis when compared with those who carried the dominant AA genotype of the same variant, and that individuals who carried the homozygous CC genotype of the A1298C variant were at risk of thrombosis, as well as the recurrent blood transfusion increased 3.8-fold when compared with those carrying the dominant AA genotype of the same SNPs due to the elevated homocysteine ​​level in patients with recurrent thrombosis.