The College of Science, Kirkuk University discussed a Ph.D. thesis on the partial purification of glutathione S-transferase enzyme in leukemia patients by the postgraduate student, Ms. Banaz Barzan Mohammed.

The thesis highlighted evaluating GST enzyme activity in leukemia patients compared to healthy individuals and studying its correlation with oxidative stress and antioxidant markers, as well as assessing liver and kidney function and several other vital signs beside performing partial purification of the enzyme and analyzing its kinetic and thermal properties, as well as studying the effect of drug interactions.

The thesis concluded that elevated GST enzyme activity in patients is associated with decreased antioxidant systems and elevated oxidative stress markers. 

The thesis reviewed the existence of a difference in the kinetic and thermal properties of the enzyme and the possibility of its activity being affected by some pharmaceutical compounds such as doxorubicin, paracetamol and benzyl chloride, as well as studying the effect of some stimulants and inducers such as vitamin C and vitamin E on its enzymatic activity.