College of Science, University of Diyala discussed a master dissertation on the biological effect of heterocyclic derivatives by the postgraduate student, Mrs. Esraa Nadhum Hamdi.

The dissertation aimed at preparing new compounds from Schiff bases of indole derivatives and choosing trimethyl indole as a starting material, which was easily modified by treatment with phosphoryl chloride to reach the compound malonaldehyde.

The dissertation demonstrated groups of organic chemicals including amino sugars (2-aminoglucose and 6-aminoglucose), branched aliphatic amines (methylamine, and 2-aminobutane), aromatic amines (aniline, benzylamine and 4-methyl-o-compounds). phenylenediamine) and amino acids (alanine, valine, and tryptophan).

The dissertation reviewed that some of the produced molecules are active as antibacterial against two types of Gram-positive bacteria and two Gram-negative bacteria, as well as anti-fungal agents, which makes this a type of chemical suitable as a potential medical agent and other target molecules showed good activity against inhibition of a cancer cell line. human liver at an optimized temperature of 310 K in 24 hours using two concentrations, making this type of molecule a candidate as a potential new anti-cancer agent suitable for medical applications.