College of Science, Mustansiriyah University discussed a Master dissertation  the evaluation of the inhibitory effect and antioxidant activities of some metal complexes derived from guanidine in patients with atherosclerosis by the postgraduate student, Ms. Shams Fahd Hassan.

The dissertation aimed at studying atherosclerosis by proposing new metal complexes for aminoguanidine and investigating the possibility of adopting them as potential inhibitors of the alkaline phosphatase enzyme and revealing the role of some important biomarkers in newly diagnosed patients to understand their relationship to the development of the disease.

The dissertation included the preparation of three metal complexes for aminoguanidine, including copper, silver and gold, and the diagnosis of the complexes using FT-IR, UV-Vis, flame atomic absorption spectroscopy, elemental analysis (C.H.N), conductivity and magnetic measurements.

The dissertation reviewed that all complexes have inhibitory properties with an advantage for the gold complex.

The dissertation  highlighted antioxidant activities of varying degrees and their IC50 values ​​were close to each other and there was a significant increase in oxLDL levels, as a result of increased oxidative stress and a significant decrease in NO, indicating a disturbance in its balance due to the effect of oxLDL, and a non-significant increase in MMP-9, due to the relationship between the enzyme's gene expression and the stage of disease progression.