College of Pharmacy, Mustansiriyah
University discussed a Ph.D. thesis on therapeutic antibodies as a selective
carrier for the anti-cancer drug Pemetrexed by the postgraduate student, Ms.
Faten Qais Ibrahim Rashid.
The thesis aimed at preparing the chemical
link between the drug Pemetrexed and antibodies in the form of needles prepared
for intravenous injection to reduce the side effects of the drug Pemetrexed and
deliver it to cancer cells by therapeutic antibodies.
The thesis reviewed that the lyophilized
formulations have high stability of their compounds when stored for a period of
6 months at a refrigeration temperature of 6° C.
The thesis concluded that the
phosphorescent fluorescence microscope preparations and Pem-PEG-AtZ, and
Pem-GABA-AtZ conjugates have the ability to deliver the treatment to cancer
cells and selectively bind to the protein materials secreted by cancer cells
PDL antigen, which means that the prepared model in the form of intravenous
injection of the drug pemetrexed linked to the antibody Atezolizumab can be an
alternative to the available intravenous pemetrexed drug, which may lead to
improve its therapeutic selectivity to affect cancer cells.
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