The thesis aimed at
studying the role of (microRNA), immune control and cytokines that control
leukemia stem cells in resistance to chemotherapy and relapse in patients with
acute myeloid leukemia, as well as evaluating the possibility of using these
factors as biomarkers for diagnosis and prognosis of the disease and
applications of targeted cancer therapy.
The thesis highlighted
that CTLA-4 protein appears at high levels in patients newly diagnosed with
acute myeloid leukemia, making it an important indicator for early detection of
the disease.
The thesis
demonstrated that the levels of mir-155 and mir-126 are significantly higher in
patients compared to healthy individuals, especially in the early stage of
diagnosis, which enhances their role as effective biomarkers in diagnosing the
disease and monitoring its development.
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